Projects & Highlights

The Chronic Brain Injury Program and our affiliated faculty, staff, and students are working to improve our understanding, detection, and treatment of brain injuries. Learn more about our key projects and our latest team successes.

Projects

Translational Research

Pilot Awards

To support innovation in basic and clinical brain injury research, CBI offers seed grants to interdisciplinary teams of scientists. These pilot projects help teams form, develop preliminary findings, and publish papers in advance of large federally- or industry-funded grants. CBI is developing a clinical trials component to these grants to help test promising drugs, devices, and non-pharmacological therapies. A full list of our pilot projects is available here.

TBI Data Repository: Deep characterization of brain injury survivorship and aging

Led by investigators Jasmeet Hayes and Scott Hayes, the TBI Data Repository aims to provide the deepest characterization of brain injury survivors as they age. The project combines blood samples, MRI and fMRI brain images, and cognitive assessments for over 200 survivors into a single biobank. This effort will enable the team, along with other investigators at Ohio State and beyond, to study this cohort over time and identify biomarkers of cognitive decline and resiliency. More information can be found at the MINDSET LAB and B-BAL LAB pages.

Seminars & Grand Rounds

CBI is building and supporting teams of researchers by convening scientists at our monthly seminars and quarterly grand rounds. These activities create collisions between scientists and clinicians from different disciplines. These connections are paramount to move discovery in the lab to interventions in the clinic or at home.

A list of upcoming presentations is here.

Paper of the Year

Each calendar year, CBI recognizes the most impactful publication by our faculty affiliates. The 2019 nominees were:

Tedeschi et al. ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS. Neuron. [WINNER]

Nemeth et al. Provider Perceptions and Domestic Violence (DV) Survivor Experiences of Traumatic and Anoxic-Hypoxic Brain Injury: Implications for DV Advocacy Service Provision. J. Aggression, Maltreatment & Trauma.
Worthen-Chaudhari et al. Partnered, adapted argentine tango dance for cancer survivors: A feasibility study and pilot study of efficacy. Clinical Biomechanics.
Watzlawick et al. Outcome heterogeneity and bias in acute experimental spinal cord injury. Neurology.
Rafiei et al. Predicting Improved Daily Use of the More Affected Arm Post-Stroke Following Constraint-Induced Movement Therapy. Physical Therapy.
Sammartino, Yeh & Krishna. Longitudinal analysis of structural changes following unilateral focused ultrasound thalamotomy. NeuroImage: Clinical.
Norden et al. Bone Marrow-Derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic Spinal Cord Injury. Neurotrauma.
Liu et al. Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity.

Community Outreach

Ohio TBI Registry: Ohio's first voluntary brain injury research registry

Traumatic brain injuries are complicated due to varied causes (falls, traffic accidents, sports injury, violence), several at-risk groups (older adults, young children, active-duty military and veterans), and under-reporting of injury. Some estimates suggest up to 50% of concussions may go unreported, but even mild traumatic brain injuries can have lasting health and life consequences. If we don't know about these injuries, we cannot help or study the survivors to improve their lives, or prevent others from injury.

To help connect injury survivors to medical care and research, CBI is developing Ohio's first voluntary registry in which brain injury survivors from around the state - or nation - can sign up to participate in research studies, regardless of if they have received care at Ohio State or other providers. Through this effort, we will improve our ability to do meaningful research for survivors who are struggling with the chronic effects of brain injury.

NeuroNights: Survivor and caregiver workshops

CBI and Ohio State's Outpatient Rehabilitation teams host monthly workshops for brain injury survivors and their families focused on promoting lifelong wellness after brain injury. Supported by undergraduate student volunteers from Buckeyes Raising Awareness in Neuroscience (BRAIN), these workshops will bring experts from across Ohio State's campus to educate and enable the brain injury community to adopt healthy behaviors, navigate financial and legal challenges, and generally encourage independent and productive living.

Learn more about NeuroNights here.

Connect & Collaborate: Community partners in research

Improving the Quality of Life of Chronically Ill Individuals Through Financial Coaching | Caezilia Loibl et al.

Brain injury, like other chronic illnesses, can result in financial challenges and caregiver burden, including debt, loss of income, and high stress. This project brings Ohio State researchers in Education & Human Ecology, John Glenn College of Public Affairs, Ohio State Extension, Kirwan Institute, and Ohio Valley Center together with community and industry partners including Brain Injury Association of Ohio, Apprisen, and WesBanco Bank to develop best practices and measure impact for financial coaching of brain injury survivors and caregivers. Patients at Ohio State are enrolled in regular financial coaching sessions that focus on setting goals and overcoming barriers to improve financial security, social participation, and quality of life.

Drum-Dance Rehabilitation | Yune Lee et al.

Demand for non-pharmacological interventions for Parkinson's disease has been increasing, as standard treatments for neurodegenerative diseases are costly and sometimes invasive. Brain injury survivors are at a higher risk for Parkinson's, so drug-free interventions can help survivors avoid and mitigate chronic effects of brain injury. This project is developing a novel therapy that combines dance and rhythmic drumming to improve outcomes and decrease financial burden of Parkinson's patients. Fostered by a partnership between Ohio State's Department of Speech & Hearing Sciences, School of Music, Wexner Medical Center, and community organizations Delay the Disease and Parkinson's Foundation of Ohio, this project features fitness classes, neuroimaging assessments, and a new service-learning course.

A Virtual Reality App to Improve Youth Concussion Recognition | Ginger Yang et al.

To address growing concerns about youth sports concussion, all 50 states have enacted concussion laws that require all athletes, parents and coaches to be educated about concussion. However, there is little guidance on how this education should be provided and often leaves youth athletes unable to recognize the signs of concussion or understand the importance of reporting. This project is developing a novel virtual reality simulation of concussion symptoms to better prepare youth to recognize and report these symptoms. This team brings together Nationwide Children's Hospital, Ohio State's School of Communication, the Mid-Ohio Select Soccer League and COSI to develop the app and test it with two youth soccer teams in advance of a large federal grant.

Education

Brain Health Hack

The Brain Health Hack is an interdisciplinary hackathon that engages undergraduate students to develop solutions for brain health. Teams of future scientists, clinicians, engineers, and coders compete on challenges over a weekend to create tools that enable better care, more powerful research, or further empower patients to live independent and productive lives.

SURF Awards

CBI Summer Undergraduate Research Fellowships (SURF) awards support the training and development of outstanding Ohio State undergraduate students through participation in basic, clinical, and translational research. Through CBI fellowships, investigators will mentor students on a research project during the summer semester. All CBI faculty affiliates are welcome to apply as mentors.

Professional Education

CBI is developing training programs and continuing education workshops for clinicians, researchers, and other professionals in the workforce. These efforts aim to combat the limited awareness and familiarity with brain injury's chronic effects, including quickly detecting and diagnosing the signs and symptoms in primary care or social services settings. The Ohio Valley Center at Ohio State features several modules, including the OSU TBI-ID method.

Projects in Development

Blast Injury in Veterans

fNIRS Imaging Core

Biomechanics Monitoring

Data Systems for Coordinated Care

OUR UNDERGRADUATE FEATURES

Chronic Brain Injury

Gabrielle Moots & VPT Children

Gabrielle Moots (Psychology, ’17) has been no stranger to the importance that research can have in our daily lives. Gabrielle is currently a research assistant in the Center for Biobehavioral Health at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, and her experiences in the lab have been crucial in directing her focus towards her passion for helping those with intellectual and developmental disabilities (IDD)....

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Chronic Brain Injury

Praneeth Madhu & Neurodegenerative Diseases

Praneeth Madhu (Neuroscience and Mathematics, ‘21) is an ambitious student from Dublin, Ohio, that has extensively studied the effects of the tau protein on neurodegenerative disorders such as Alzheimer’s Disease (AD). Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) caused by collections of proteins have been implicated in many neurodegenerative diseases...

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Chronic Brain Injury

Antonia Zouridakis & Injury to the CNS

Antonia Zouridakis (Neuroscience, ‘21) may have been born in Houston, Texas – but she has had no problem making the Tedeschi Laboratory feel like home. Antonia’s research efforts have focused on the structural changes seen in the brain and spinal cord after an ischemic stroke (arterial blockage) and the potential for axon regeneration. The brain and spinal cord are part of what is called the central nervous system (CNS), and injury to the CNS often results in irreparable damage. This inability to recover functioning to the injured areas is largely attributed to behavior of the axons of neurons...

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Chronic Brain Injury

Starr Jiang & the Aging Brain

Starr Jiang (Neuroscience, ’20) is the epitome of a hard worker. As a part of the Godbout Laboratory at Ohio State, Starr has helped study the mechanisms that can explain why the elderly have a harder time recovering from peripheral infections – and how this can lead to fall-related brain injuries. The lengthened recovery time of elderly patients often leads to longer hospital stays, where they average 1.5 falls per year and greatly increase their risk for TBI. In this project, the Godbout Laboratory aims to investigate the characteristics of the aged brain that may play a role in the breakdown of the brain’s ability to communicate effectively with the immune system...

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Chronic Brain Injury

Liam Stalker & Project Wander

Liam Stalker (Neuroscience '20) has been nothing short of purposeful in his final semester at The Ohio State University. At the 2020 Brain Health Hack, Liam and his team met the challenge to surpass the typical MWM and design a MWM for human subjects research. Many are familiar with the behavioral procedure known as the Morris water maze (MWM) – a task normally used with rodents to observe their ability to navigate an unknown space and track their movements. Liam and his team worked together to design “Project Wander,” a virtual reality simulation of the MWM using motion-tracking technology available in VR headsets like the Oculus Quest. Project Wander aimed to improve upon its predecessor, NavWell, by incorporating a physical motion component that allows its subjects to physically explore without disruptions or limitations...

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Highlights

Read more about the latest successes of our program and research teams.

2019 CBI Paper of the Year

Andrea Tedeschi, PhD., Assistant Professor of Neuroscience, won the 2019 CBI Paper of the Year for his work, "ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS", which was published in Neuron. This work described essential mechanisms for axonal regeneration in neurons following central nervous system injury, which may inform future regenerative interventions. Several publications were nominated for this annual award, and are listed on our Projects & Highlights page. Read Dr. Tedeschi's paper at the link below.

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Ohio State receives inaugural NIH/NEA Sound Health Initiative award

CBI faculty Yune Lee (Speech & Hearing Sciences) received an NIH R21 award to study the neural mechanisms underlying language recovery through rhythm therapy for people with aphasia. Aphasia is a language disorder common in moderate and severe brain injury that limits a person's ability to speak - but many people with aphasia can sing. Dr. Lee and his collaborators are testing if rhythm-based therapy delivered through a video game, TheraBeat, will create subsequent changes in brain function using fMRI and fNIRS imaging. This is one of 15 inaugural awards through the Sound Health Initiative, which features a partnership between NIH and the National Endowment for the Arts.

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Brain injury common in domestic violence

New research by CBI affiliate Julianna Nemeth suggests that brain injury caused by blows to the head and by oxygen deprivation are likely ongoing health issues for many domestic violence survivors. Because of poor recognition of these lasting harms, some interactions between advocates and women suffering from the effects of these unidentified injuries were likely misguided.

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Insights: Rhythm-based therapy for aphasia

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Insights: Scalpel-free Surgery for Brain Health

Vibhor Krishna, MD is featured by Ohio State Insights for his work on developing focused ultrasound technology that can remove diseased or cancerous brain tissue, restore fine movement, and help deliver medications to the brain. People living with complications from brain injury such as movement disorders and Alzheimer's may benefit from these techniques in the future.

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CBI 2019 Summer Undergraduate Research Fellows

CBI launched its Summer Undergraduate Research Fellowships (SURF) Awards in Spring 2019 to support training and development of outstanding Ohio State undergraduates through participation in basic, clinical, and translational research. SURF Fellows complete a research project with CBI faculty mentors during the summer semester. Congratulations to the inaugural SURF Fellows who will each receive $4,000 stipends for their project. Sebastian Bejarano, College of Engineering (Mentor: Liang Guo, PhD) Mahin Hossain, College of Medicine (Mentor: Jan Schwab, MD, PhD) Praneethkumar Madhu, College of Medicine (Mentor: Harry Fu, PhD) Matthew Moritz, College of Arts & Science (Mentor: Yune Lee, PhD)

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CBI 2019 Brain Health Hack Winners

CBI's annual weekend workshop for undergraduates saw teams build and develop mobile and virtual reality applications that address brain health research and clinical needs. Teams often bridged engineering and health sciences disciplines, and completed their applications in under 20 hours. Several projects were suggested by Ohio State and Nationwide Children's Hospital faculty, and successful teams will continue to develop their work in partnership with the sponsors. Congratulations to winning teams 119, Project Velvet, and VrNS!

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Student Succeeds in Game-Based Rehabilitation

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CBI 2018 Paper of the Year

Congratulations to Harry Fu, PhD, for winning the CBI 2018 Paper of the Year! Harry is an Assistant Professor in the Department of Neuroscience, and was awarded $500 and a plaque for his accomplishment. This award recognizes scientific impact and contribution to chronic brain injury research.

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Jonathan Godbout named interim faculty director for Chronic Brain Injury

Jonathan Godbout, PhD, has been named interim faculty lead of the Chronic Brain Injury (CBI) program, a focus area of the $500 million Discovery Themes initiative created by Ohio State to address global challenges.

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New Thoughts About Brain Disorders: Electrical Engineering Research Delves into Mind

People with brain disorders such as Alzheimer’s and Parkinson’s disease could probably tell you about the limitations of current treatments. But what if they could have better options in the future — options beyond currently approved medications or devices?

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CBI affiliate Lise Worthen-Chaudhari awarded 2016 Early Career Innovator of the Year

As Ohio State continues to expand its role in the commercialization of research, it is important to create an environment that facilitates and rewards research creativity and entrepreneurship. To support and stimulate entrepreneurial activity among Ohio State researchers, three university-wide awards were presented on January 25, 2017, to Ohio State’s most successful entrepreneurs.

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Subtle hearing loss while young changes brain function

Cranking up your headphones or scrambling for a front-row spot at rock shows could be damaging more than your hearing. "Hearing loss, even minor deficits, can take a toll in young people - they're using cognitive resources that could be preserved until much later in life," says Yune Lee, a CBI affiliate and assistant professor in Speech & Hearing Sciences. "Most concerning, this early hearing loss could pave the way for dementia."

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