Contact: Anthony Brown, PhD | Neuroscience | firstname.lastname@example.org
Established in 2004 and funded by a P30 Center Core grant from the National Institutes of Neurological Disorders and Stroke, the Ohio State University Neuroscience Center Core is a vital hub for neuroscience research and collaboration across campus, providing specialized expertise and services that support research into the causes and treatments of neurological disorders
The Center consists of an Administrative Core and four Scientific Cores that are managed by highly trained and experienced staff. These cores serve a broad and collaborative community of more than 40 neuroscientists including approximately 30 PIs on approximately 40 NIH-funded neuroscience projects totaling approximately $12 million in annual NIH funding.
A key feature of these Cores is their flexible service model, which allows them to perform procedures for users or to train users that wish to perform the procedures in the Core facility or in their own laboratories. In this way, the Cores maximize efficiency, offering centralized access to equipment and expertise that would be difficult, costly or impractical to duplicate in individual laboratories, while at the same time providing standardized protocols and ensuring uniform application of best practices so that experiments are performed to the highest standards.
By making these services available to investigators, the Center also encourages the adoption of a broader range of technical approaches by individual investigators, strengthening NINDS-funded research on campus and furthering or expanding the scope of NINDS-funded and other neuroscience projects.
Center for Cognitive & Behavioral Brain Imaging
Contact: Ruchika Prakash, PhD | Psychology | email@example.com
The Center for Cognitive and Behavioral Brain Imaging (CCBBI) in the College of Arts and Sciences is a new state-of-the art interdisciplinary research facility dedicated to pursuing structural and functional magnetic resonance imaging (fMRI) studies. It aims to contribute to the development of future brain imaging modalities and to create and disseminate knowledge about brain, mind, and imaging research.
The study of brain functioning and behavior (cognitive neuroscience), is one of the fastest growing fields in psychology and the social and biological sciences more generally. A major contributor to this growth is the development of innovative functional Magnetic Resonance Imaging (fMRI) technology. With a Siemens 3T Prisma system and ancillary equipment to support research spanning the cognitive and behavioral sciences, CCBBI is dedicated to the study of brain mechanisms underlying individuals' cognitive capacity and subjective well-being, as well as dysfunctions of these brain mechanisms in normal aging and mental disorders. CCBBI is open to all scholars exploring the relationship between the human brain and behavior.
Zeiss Apotome.2 Microscope
Contact: Elizabeth Kirby, PhD | Psychology | firstname.lastname@example.org
An essential aspect of repairing brain injury is quantifying tissue damage and recovery in experimental paradigms. Microscopy provides a powerful way to visualize the brain in situ using postmortem tissue sections. However, when imaging thick tissue sections, out-of-focus light can make images blurry, obscuring important details in the in-focus plane. Confocal microscopes address the problem of out-of-focus light by using high-precision lasers to create thin optical sections. While confocal technology provides excellent imaging, it is time-consuming, damaging to samples, expensive and high maintenance.
The Zeiss Apotome is a microscope that offers high resolution imaging similar to that of traditional confocal microscopy but in a fraction of the time and with less damage to fluorescent signal. The Apotome uses a traditional fluorescence microscope coupled with a hardware add-on (the apotome) and deconvolution algorithms to create high resolution z-stacks, yielding well-focused images through thick tissue sections. This process yields images 20-50 times faster than traditional confocal technology with only a small loss in resolution.
Olympus FVMPE-RS Multiphoton Laser Scanning Microscope
Contact: Karl Obrietan, PhD | Neuroscience | email@example.com
The Olympus FVMPE-RS multiphoton imaging system is purpose-built for deep imaging in biological tissue, aimed at revealing both detail and dynamics. Innovative features for efficient delivery and detection of photons in scattering media enable high signal-to-noise ratio acquisition. This translates to bright images with precise details — even from deep within the specimen. High sensitivity is matched with high-speed imaging to capture rapid in vivo responses.
Contact: Yune Lee, PhD | Speech & Hearing Sciences | firstname.lastname@example.org
Functional near-infrared spectroscopy (fNIRS) is an emerging neuroimaging technology that optically measures brain function similar to fMRI (BOLD signal). Ohio State's LABNIRS device offers a powerful fNIRS system that allows investigators to study brain function during seated and standing tasks, at a patient's bedside, or on a sideline. Investigators can also study people unable to undergo MR imaging due to age, implanted devices, or other restrictions.
Closed Head Impact Modela of Engineered Rotational Acceleration (CHIMERA) - coming soon!
Contact: Olga Kokiko-Cochran, PhD | Neuroscience | email@example.com
CHIMERA is a translationally relevant platform for human traumatic brain injury (TBI) research. CHIMERA was specifically designed to overcome many of the caveats that limit the translational relevance of most existing TBI models. CHIMERA's innovation lies in its ability to generate, in a biomechanically controlled and reproducible manner, a wide range of TBI severity with completely free head movement.
Pilot & Equipment Grants
Fellowships & Travel Awards
CBI offers faculty affiliates professional development opportunities at no charge. Past offerings range from free headshots to multi-session speaker trainings. These opportunities are offered 1-2 times per semester - please contact CBI staff if you would like to learn more or if you have an idea for a future offering.