Ohio State CBI

FUNDING & RESOURCES

We engage in fundamental and applied research to understand how brain injury leads to chronic conditions, to create new technologies that detect and treat injury, or explore new therapies and prevention measures. CBI provides seed funding for cross-college collaborations that push the boundaries of our knowledge and capabilities in brain injury research. CBI also offers equipment cost-share funding, travel awards, undergraduate summer fellowships, and other resources to our members.

2021 CBI Pilot Projects

Congratulations to our 2021 Pilot Award winners! These interdisciplinary teams will develop innovative brain injury research in human imaging, movement analysis, and infection risks.

  • A bedside multimodal imaging approach for detection and evaluation of ischemic and hemorrhagic stroke - ​​​Yousef Hannawi and Emre Ertin

  • A multi-functional electronic tattoo for spasticity tracking and management in severe TBI patients - Jinghua Li and William Zev Rymer

  • PROJECT TITLE COMING SOON! - Olga Kokiko-Cochran, Dana McTigue and Iryna Crescenze

  • FORM: Flexion sensors for monitoring on-field activities following return to play from mTBI - Jaclyn Caccese and Asimina Kiourti

  • Understanding the neurodevelopmental effects of football-related neurotrauma across first year of tackle football participation - Jaclyn Caccese and Zeynep Saygin

  • Counteracting Maladaptive Plasticity and Chronic Neurodegeneration Following Brain and Spinal Cord Injury Using a "Smart" Drug Delivery System (SDDS)
    Andrea Tedeschi, Neuroscience
    John Lannutti, Materials Science & Engineering
    Craig McElroy, Pharmacy
  • Pilot Study for Empowering Survivors of Traumatic Brain Injury to be Physically Literate and Active for All Years (TBI-PLAAY)
    Catherine Quatman-Yates, Physical Therapy
    Jennifer Bogner, Physical Medicine & Rehabilitation
    Leeann Lower-Hoppe, Sports & Exercise Management
    Laura Schmitt, Physical Therapy
    Lise Worthen-Chaudhari, Physical Medicine & Rehabilitation
  • Optical Coherence Tomography for the Diagnosis of Chronic Traumatic Encephalopathy
    Andrew Sas, Neurology
    Kevin Weber, Neurology
    Stacey Choi, Optometry
    Nathan Doble, Optometry
  • Embodied Effects Of Rhythmic Music Among Adults With Brain Injury
    Lise Worthen-Chaudhari, Physical Medicine & Rehabilitation
    Eugenia Costa-Giomi, Music Education
    W. Jerry Mysiw, Physical Medicine & Rehabilitation
    Catherine Quatman-Yates, Physical Therapy
    Jinghua Li, Materials Science & Engineering
    Asimnia Kiourti, Electrical & Computer Engineering
  • Assessing Needs of FQHCs to Become Partners in Chronic Brain Injury Detection and Rehabilitation among Domestic Violence Survivors
    Juliana Nemeth, Health Behavior & Health Promotion
    Rachel Ramirez, Ohio Domestic Violence Network
  • Effects of adolescent traumatic brain injury on the maturation of executive functions and modulation by social stress
    Laurence Coutellier, Psychology
    Jon Godbout, Neuroscience
  • Long-term Neurobiological Outcomes Among OSU Student Athletes with Concussion
    Jasmeet Hayes, Psychology
    John Corrigan, Physical Medicine & Rehabilitation
    Tatiana Wolfe, Center for Cognitive & Behavioral Brain Imaging
  • Reproductive Experience and Traumatic Brain Injury in Females
    Benedetta Leuner, Psychology
    Olga Kokiko-Cochran, Neuroscience
  • DTRI-03 Dosing in Canine Middle Cerebral Artery Occlusion
    Shahid Nimjee, Neurological Surgery
    Cameron Rink, Surgery
    Bob Hamlin, Veterinary Medicine
    Zhong-Lin Lu, Psychology
  • Trajectory of Salivary miRNA Expressions in Children with Concussion
    Ginger Yang, Nationwide Children's Hospital
    Zhong-Lin Lu, Psychology
    Elaine Mardis, Nationwide Children's Hospital
    James MacDonald, Nationwide Children's Hospital
  • Propagation of pathological tau strains from Alzheimer's disease and traumatic brain injury in cerebral organoids
    Hongjun Fu, Neuroscience
    Doug Scharre, Neurology
    Mark Hester, Nationwide Children's Hospital
  • Synaptrode: A Synaptomimetic Neural Interface with Programmable Plasticity
    Liang Guo, Electrical & Computer Engineering
    Min Zhou, Neuroscience
  • Early life traumatic injury: sex differences, immune cells, and neurobehavioral outcomes across the lifespan
    Kathryn Lenz, Psychology
    Olga Kokiko-Cochran, Neuroscience
  • Infrared Hyperspectral Imaging for In Vivo Detection of Neuromarkers of Cerebral Ischemia
    TJ Ronningen, Electrical & Computer Engineering
    Tatiana Wolfe, Center for Cognitive & Behavioral Brain Imaging
    Daniel Prevedello, Neurological Surgery
    Sanjay Krishna, Electrical & Computer Engineering
  • Effectiveness of a psychological intervention for children with post-concussion syndrome
    Sean Rose, Nationwide Children's Hospital
    Kelly McNally, Nationwide Children's Hospital
    Zeynep Saygin, Psychology
    Ginger Yang, Nationwide Children's Hospital
  • Ultrastructural characterization of iron in Alzheimer's disease
    Gunjan Agarwal, Biomedical Engineering
    Dana McTigue, Neuroscience
  • Noninvasive brain stimulation for chronic symptoms of acquired brain injury
    Marcia Bockbrader, Physical Medicine & Rehabilitation
    David Kline, Biostatistics
    Liang Guo, Electrical & Computer Engineering
  • Anti-nitrative neuroprotective activity of γ-tocopherol in ischemic stroke
    Richard Bruno, Human Nutrition
    Cameron Rink, Surgery
  • Chronic post-injury sleep disruption (SD) as a catalyst for neurodegenerative disease
    Olga Kokiko-Cochran, Neuroscience
    John Sheridan, Biosciences (Dentistry)
  • Translation of VWF aptamer into large animal stroke model
    Shahid Nimjee, Neurological Surgery
    Bob Hamlin, Veterinary Biosciences,
    Cameron Rink, Surgery
    Zhong-Lin Lu, Psychology
    Jay Zweier, Internal Medicine
  • Age-related differences in torsional indirect traumatic optic neuropathy
    Matthew Reilly, Biomedical Engineering
    Colleen Cebulla, Ophthalmology & Visual Science
    Mohamed Abdel-Rahman, Ophthalmology & Visual Science
    Julie Racine, Ophthalmology (Nationwide Children's Hospital)
    Nathan Doble, Optometry
    Stacey Choi, Optometry
  • Cerebrospinal fluid markers of synaptic injury and functional connectivity in Alzheimer's disease
    Rawan Tarawneh, Neurology
    Douglas Scharre, Neurology
    Zhong-Lin Lu, Psychology
  • Investigating compensatory language processes prompted by rhythm video game therapy in chronic aphasia
    Yune Lee, Speech and Hearing Sciences
    Stacy Harnish, Speech and Hearing Sciences
    Lynne Gauthier, Physical Medicine & Rehabilitation
    Roger Crawfis, Computer Science & Engineering
  • Small molecule activators of glutamate transporter EAAT2 for Alzheimer's disease
    Glenn Lin, Neuroscience
    John Bruno, Psychology
    Min Zhou, Neuroscience
  • Mechanisms underlying hippocampal cell layer-specific sensitivity to ischemic stroke
    Karl Obrietan, Neuroscience
    Kari Hoyt, Pharmacology

Pre-projects

  • Driving performance after concussion in teens
    Ginger Yang, Pediatrics (Nationwide Children's Hospital)
    Keith Yeates, Psychology (Nationwide Children's Hospital)
    Richard Rodenberg, Pediatrics (Nationwide Children's Hospital)
    James McDonald, Pediatrics (Nationwide Children's Hospital)
    Thomas Kerwin, Ohio Supercomputer Center
    Don Stredney, Ohio Supercomputer Center
    Michael Tiso, Sports Medicine
    Jennifer Bogner, Physical Medicine & Rehabilitation
  • The effect of KATP channel manipulation on neuroprotection after stroke
    Shahid Nimjee, Neurosurgery
    Keli Hu, Pharmacology
    Cameron Rink, Surgery
    Chanden Sen, Surgery
  • Neurocognitive versus neuromuscular deficits following mild traumatic brain injury
    Asimina Kiourti, Electrical & Computer Engineering
    James Onate, Physical Therapy
    Stephanie Di Stasi, Sports Medicine
    Michael Tiso, Sports Medicine
  • Hojjat Adeli, Alexandra Borstad, John Buford
    Computer aided prediction of sensory correlates of motor recovery following constraint induced movement therapy in chronic stroke
    Civil, Environmental & Geodetic Engineering, Physical Therapy
  • Daniel Gallego-Perez, L. James Lee, Savita Khanna, Cameron Rink
    Pro-angiogenic cell therapies for stroke recovery: Nanoengineering blood vessels through direct reprogramming
    Biomedical Engineering, Chemical & Biomolecular Engineering, Surgery
  • Jonathan Godbout, John Sheridan, Daniel Eiferman
    The Elimination of Microglia by a CSF-1R antagonist to prevent or reverse TBI-induced chronic inflammation associated with microglia priming and reactivity
    Neuroscience, Dentistry, Surgery
  • Cameron Rink, Savita Khanna, David McComb
    Characterization of collateral remodeling in the stroke-affected brain
    Surgery, Materials Science & Engineering
  • Zachary Weil, Kari Hoyt
    Mitochondrial dysfunction mediated by insulin resistance in repeated traumatic brain injury
    Neuroscience, Pharmacology

The 2021 CBI SURF Fellows are:

Akshaykumar Ganesh | Neuroscience

Mentor: Jan M. Schwab, MD, PhD | Neurology

LEARN MORE ABOUT THE SCHWAB LAB

Maria Weibel | Nursing

Mentor: Judith Tate, PhD | Nursing

LEARN MORE ABOUT DR. JUDITH TATE

Brooke Schatz | Neuroscience

Mentor: Kathryn M. Lenz, PhD | Psychology

LEARN MORE ABOUT THE LENZ LAB

Gregory Owendoff | Biomedical Science

Mentor: W. Dave Arnold, MD | Neurology

LEARN MORE ABOUT THE ARNOLD LAB

Tony Han | Electrical and Computer Engineering

Mentor: Asimina Kiourti, PhD | Electrical and Computer Engineering

LEARN MORE ABOUT THE WIT LAB

OUR RESOURCES

CBI awards travel funds for faculty affiliates and their lab members to present chronic brain injury research at national and international conferences. These awards are available to defray attendance costs for in-person and virtual presentations. Each CBI-affiliated lab is eligible for one award per year.

TRAVEL AWARD APPLICATION

Neuroscience Core

Contact: Anthony Brown, PhD | Neuroscience | brown.2302@osu.edu

NEUROSCIENCE CORE SERVICES

Established in 2004 and funded by a P30 Center Core grant from the National Institutes of Neurological Disorders and Stroke, the Ohio State University Neuroscience Center Core is a vital hub for neuroscience research and collaboration across campus, providing specialized expertise and services that support research into the causes and treatments of neurological disorders

The Center consists of an Administrative Core and four Scientific Cores that are managed by highly trained and experienced staff. These cores serve a broad and collaborative community of more than 40 neuroscientists including approximately 30 PIs on approximately 40 NIH-funded neuroscience projects totaling approximately $12 million in annual NIH funding.

A key feature of these Cores is their flexible service model, which allows them to perform procedures for users or to train users that wish to perform the procedures in the Core facility or in their own laboratories. In this way, the Cores maximize efficiency, offering centralized access to equipment and expertise that would be difficult, costly or impractical to duplicate in individual laboratories, while at the same time providing standardized protocols and ensuring uniform application of best practices so that experiments are performed to the highest standards.

By making these services available to investigators, the Center also encourages the adoption of a broader range of technical approaches by individual investigators, strengthening NINDS-funded research on campus and furthering or expanding the scope of NINDS-funded and other neuroscience projects.

Center for Cognitive and Behavioral Brain Imaging

Contact: Ruchika Prakash, PhD | Psychology | prakash.30@osu.edu

The Center for Cognitive and Behavioral Brain Imaging (CCBBI) in the College of Arts and Sciences is a new state-of-the art interdisciplinary research facility dedicated to pursuing structural and functional magnetic resonance imaging (fMRI) studies. It aims to contribute to the development of future brain imaging modalities and to create and disseminate knowledge about brain, mind, and imaging research.

The study of brain functioning and behavior (cognitive neuroscience), is one of the fastest growing fields in psychology and the social and biological sciences more generally. A major contributor to this growth is the development of innovative functional Magnetic Resonance Imaging (fMRI) technology. With a Siemens 3T Prisma system and ancillary equipment to support research spanning the cognitive and behavioral sciences, CCBBI is dedicated to the study of brain mechanisms underlying individuals' cognitive capacity and subjective well-being, as well as dysfunctions of these brain mechanisms in normal aging and mental disorders. CCBBI is open to all scholars exploring the relationship between the human brain and behavior.

Zeiss Apotome.2 Microscope

Contact: Elizabeth Kirby, PhD | Psychology | kirby.224@osu.edu

An essential aspect of repairing brain injury is quantifying tissue damage and recovery in experimental paradigms. Microscopy provides a powerful way to visualize the brain in situ using postmortem tissue sections. However, when imaging thick tissue sections, out-of-focus light can make images blurry, obscuring important details in the in-focus plane. Confocal microscopes address the problem of out-of-focus light by using high-precision lasers to create thin optical sections. While confocal technology provides excellent imaging, it is time-consuming, damaging to samples, expensive and high maintenance.

The Zeiss Apotome is a microscope that offers high resolution imaging similar to that of traditional confocal microscopy but in a fraction of the time and with less damage to fluorescent signal. The Apotome uses a traditional fluorescence microscope coupled with a hardware add-on (the apotome) and deconvolution algorithms to create high resolution z-stacks, yielding well-focused images through thick tissue sections. This process yields images 20-50 times faster than traditional confocal technology with only a small loss in resolution.

Olympus FVMPE-RS Multiphoton Laser Scanning Microscope​

Contact: Karl Obrietan, PhD | Neuroscience | obrietan.1@osu.edu

The Olympus FVMPE-RS multiphoton imaging system is purpose-built for deep imaging in biological tissue, aimed at revealing both detail and dynamics. Innovative features for efficient delivery and detection of photons in scattering media enable high signal-to-noise ratio acquisition. This translates to bright images with precise details — even from deep within the specimen. High sensitivity is matched with high-speed imaging to capture rapid in vivo responses.

Shimadzu LABNIRS

Contact: Yune Lee, PhD | Speech & Hearing Sciences | lee.7966@osu.edu

Functional near-infrared spectroscopy (fNIRS) is an emerging neuroimaging technology that optically measures brain function similar to fMRI (BOLD signal). Ohio State's LABNIRS device offers a powerful fNIRS system that allows investigators to study brain function during seated and standing tasks, at a patient's bedside, or on a sideline. Investigators can also study people unable to undergo MR imaging due to age, implanted devices, or other restrictions.

Closed Head Impact Modela of Engineered Rotational Acceleration (CHIMERA)

Contact: Olga Kokiko-Cochran, PhD | Neuroscience | olga.kokiko-cochran@osumc.edu

CHIMERA is a translationally relevant platform for human traumatic brain injury (TBI) research. CHIMERA was specifically designed to overcome many of the caveats that limit the translational relevance of most existing TBI models. CHIMERA's innovation lies in its ability to generate, in a biomechanically controlled and reproducible manner, a wide range of TBI severity with completely free head movement.

Current Offerings

CBI offers our faculty affiliates professional development opportunities at no charge. Past offerings range from free headshots to multi-session speaker trainings. These opportunities are offered 1-2 times per semester.

Please contact CBI staff if you would like to learn more or if you have an idea for a future offering.