Ohio State CBI
FUNDING & RESOURCES
We engage in fundamental and applied research to understand how brain injury leads to chronic conditions, to create new technologies that detect and treat injury, or explore new therapies and prevention measures. CBI provides seed funding for cross-college collaborations that push the boundaries of our knowledge and capabilities in brain injury research. CBI also offers equipment cost-share funding, travel awards, undergraduate summer fellowships, and other resources to our members.
PILOT AWARDS
The CBI pilot award program supports the innovation and interdisciplinary collaboration that fosters outstanding basic, clinical, and translational research. Within these internal grants, teams of investigators will develop cross-college collaborations and pilot data in pursuit of impactful research projects and programs. All university faculty are encouraged to submit proposals for new projects that address chronic brain injury topics.
To apply, please read and complete the documents and forms linked below.
Research Pilot Winners
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Immune signaling mechanisms in cerebrovascular disease
Yousef Hannawi, MD (Neurology) and Daniel Gallego-Perez, PhD (Biomedical Engineering) -
Hippocampal stem cell function
Liz Kirby, PhD (Psychology) and Wenjing Sun, PhD (Neuroscience) -
Blast injury in first responders
Jaclyn Caccese, PhD (Health & Rehabilitation Sciences), Josh Hagen, PhD (Human Performance Collaborative), Jimmy Onate, PhD (Sports Medicine)
Inaugural Clinical Pilot Winner
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Characterizing neuroimmune function in chronic spinal cord injury patients
Jan Schwab, MD, PhD (Neurology) and Phillip Popovich, PhD (Neuroscience)
Summer 2021
The discovery of tau aggregration inhibitors by molecular simulation and experimental verification
Jie Gao, PhD (Neuroscience), Junmei Wang, PhD (University of Pittsburgh)
Determining the Role of the Gut Microbiome in TBI-induced Cognitive Impairment
Kris Martens, PhD (Neuroscience), Michael Bailey, PhD (Nationwide Children's Hospital), Cole Vonder Haar, PhD (Neuroscience)
Measuring Cognitive Activity Workload in Children with Concussion
Asimina Kiourti, PhD (Electrical & Computer Engineering), Ginger Yang, PhD (Nationwide Children's Hospital), Daniel Cohen, PhD (Nationwide Children's Hospital)
Divergent responses to CNS injury: region-specific and sex-specific microglia transcriptional phenotypes
Faith Brennan, PhD (Neuroscience), Kathryn Lenz, PhD (Psychology), Olga "Niki" Kokiko-Cochran, PhD (Neuroscience)
Assessing Readiness to Transition to Physical Activity Post-Concussion in Youth
Ginger Yang, PhD (Nationwide Children's Hospital), Catie Quatman-Yates, PhD (Health & Rehabiliation Sciences), Daniel Cohen, PhD (Nationwide Children's Hospital), Hudson Taylor, PhD (Nationwide Children's Hospital), Keith Yeates, PhD (Nationwide Children's Hospital)
Winter 2021
A bedside multimodal imaging approach for detection and evaluation of ischemic and hemorrhagic stroke
Yousef Hannawi, MD (Neurology), Emre Ertin, PhD (Electrical & Computer Engineering)
A multi-functional electronic tattoo for spasticity tracking and management in severe TBI patients
Jinghua Li, PhD (Materials Science Engineering), William Zev Rymer, MD, PhD
Injury and Infection Interactions (FULL TITLE COMING SOON!)
Olga "Niki" Kokiko-Cochran, PhD (Neuroscience), Dana McTigue, PhD (Neuroscience), Iryna Crescenze, MD (Urology)
FORM: Flexion sensors for monitoring on-field activities following return to play from mTBI
Jaclyn Caccese, PhD (Health & Rehabilitation Sciences), Asimina Kiourti, PhD (Electrical & Computer Engineering)
Understanding the neurodevelopmental effects of football-related neurotrauma across first year of tackle football participation
Jaclyn Caccese, PhD (Health & Rehabilitation Sciences), Zeynep Saygin, PhD (Psychology)
- Counteracting Maladaptive Plasticity and Chronic Neurodegeneration Following Brain and Spinal Cord Injury Using a "Smart" Drug Delivery System (SDDS)
Andrea Tedeschi, Neuroscience
John Lannutti, Materials Science & Engineering
Craig McElroy, Pharmacy - Pilot Study for Empowering Survivors of Traumatic Brain Injury to be Physically Literate and Active for All Years (TBI-PLAAY)
Catherine Quatman-Yates, Physical Therapy
Jennifer Bogner, Physical Medicine & Rehabilitation
Leeann Lower-Hoppe, Sports & Exercise Management
Laura Schmitt, Physical Therapy
Lise Worthen-Chaudhari, Physical Medicine & Rehabilitation - Optical Coherence Tomography for the Diagnosis of Chronic Traumatic Encephalopathy
Andrew Sas, Neurology
Kevin Weber, Neurology
Stacey Choi, Optometry
Nathan Doble, Optometry - Embodied Effects Of Rhythmic Music Among Adults With Brain Injury
Lise Worthen-Chaudhari, Physical Medicine & Rehabilitation
Eugenia Costa-Giomi, Music Education
W. Jerry Mysiw, Physical Medicine & Rehabilitation
Catherine Quatman-Yates, Physical Therapy
Jinghua Li, Materials Science & Engineering
Asimnia Kiourti, Electrical & Computer Engineering - Assessing Needs of FQHCs to Become Partners in Chronic Brain Injury Detection and Rehabilitation among Domestic Violence Survivors
Juliana Nemeth, Health Behavior & Health Promotion
Rachel Ramirez, Ohio Domestic Violence Network
- Effects of adolescent traumatic brain injury on the maturation of executive functions and modulation by social stress
Laurence Coutellier, Psychology
Jon Godbout, Neuroscience - Long-term Neurobiological Outcomes Among OSU Student Athletes with Concussion
Jasmeet Hayes, Psychology
John Corrigan, Physical Medicine & Rehabilitation
Tatiana Wolfe, Center for Cognitive & Behavioral Brain Imaging - Reproductive Experience and Traumatic Brain Injury in Females
Benedetta Leuner, Psychology
Olga Kokiko-Cochran, Neuroscience - DTRI-03 Dosing in Canine Middle Cerebral Artery Occlusion
Shahid Nimjee, Neurological Surgery
Cameron Rink, Surgery
Bob Hamlin, Veterinary Medicine
Zhong-Lin Lu, Psychology - Trajectory of Salivary miRNA Expressions in Children with Concussion
Ginger Yang, Nationwide Children's Hospital
Zhong-Lin Lu, Psychology
Elaine Mardis, Nationwide Children's Hospital
James MacDonald, Nationwide Children's Hospital - Propagation of pathological tau strains from Alzheimer's disease and traumatic brain injury in cerebral organoids
Hongjun Fu, Neuroscience
Doug Scharre, Neurology
Mark Hester, Nationwide Children's Hospital - Synaptrode: A Synaptomimetic Neural Interface with Programmable Plasticity
Liang Guo, Electrical & Computer Engineering
Min Zhou, Neuroscience - Early life traumatic injury: sex differences, immune cells, and neurobehavioral outcomes across the lifespan
Kathryn Lenz, Psychology
Olga Kokiko-Cochran, Neuroscience - Infrared Hyperspectral Imaging for In Vivo Detection of Neuromarkers of Cerebral Ischemia
TJ Ronningen, Electrical & Computer Engineering
Tatiana Wolfe, Center for Cognitive & Behavioral Brain Imaging
Daniel Prevedello, Neurological Surgery
Sanjay Krishna, Electrical & Computer Engineering - Effectiveness of a psychological intervention for children with post-concussion syndrome
Sean Rose, Nationwide Children's Hospital
Kelly McNally, Nationwide Children's Hospital
Zeynep Saygin, Psychology
Ginger Yang, Nationwide Children's Hospital
- A biological neuroprosthesis for restoring cognitive function in learning and memory
Liang Guo, Electrical & Computer Engineering
Min Zhou, Neuroscience - Automated segmentation of MRI features of cerebral small vessel disease in patients with acute ischemic stroke
Yousef Hannawi, Neurology
Kimerly Powell, Biomedical Informatics
James Odei, Biostatistics (Public Health) - Quantifying the hippocampal neural stem cell transcriptome after TBI
Liz Kirby, Psychology
Olga "Niki" Kokiko-Cochran, Neuroscience - Brain functional connectivity and self-management in African Americans with Alzheimer's Disease and related dementia disorders and hypertension
Kathy Wright, Nursing
Lorraine Mion, Nursing
Alai Tan, Nursing
Doug Scharre, Neurology
Zhong-Lin Lu, Psychology - Impact of virtual reality on adherence to mindfulness practices: a proof-of concept randomized controlled trial
Marcie Bockbrader, Physical Medicine & Rehabilitation
Susan Melsop, Design
Ruchika Prakash, Psychology - Pupil responses to red and blue light in adolescent hockey players measured before, during and after one year of league play with body checking
Andrew Hartwick, Optometry
Catherine McDaniel, Optometry
James MacDonald, Sports Medicine (Nationwide Children's Hospital)
Zeynep Saygin, Psychology - Batteryless impedance matching for wireless brain implants
Asimina Kiourti, Electrical & Computer Engineering
Vibhor Krishna, Neurological Surgery - Novel interventions for mild traumatic brain injury
Lise Worthen-Chaudhari, Physical Medicine & Rehabilitation
W. Jerry Mysiw, Physical Medicine & Rehabilitation
Yune Lee, Speech & Hearing Sciences - Neuroprotective role of a novel antioxidant nanoscaffold in Alzheimer's disease
Ouliana Ziouzenkova, Human Sciences
Jonathan Parquette, Chemistry & Biochemistry
Chen Gu, Biological Chemistry & Pharmacology
Sung Ok Yoon, Biological Chemistry & Pharmacology
- Ultrastructural characterization of iron in Alzheimer's disease
Gunjan Agarwal, Biomedical Engineering
Dana McTigue, Neuroscience - Noninvasive brain stimulation for chronic symptoms of acquired brain injury
Marcia Bockbrader, Physical Medicine & Rehabilitation
David Kline, Biostatistics
Liang Guo, Electrical & Computer Engineering - Anti-nitrative neuroprotective activity of γ-tocopherol in ischemic stroke
Richard Bruno, Human Nutrition
Cameron Rink, Surgery - Chronic post-injury sleep disruption (SD) as a catalyst for neurodegenerative disease
Olga Kokiko-Cochran, Neuroscience
John Sheridan, Biosciences (Dentistry) - Translation of VWF aptamer into large animal stroke model
Shahid Nimjee, Neurological Surgery
Bob Hamlin, Veterinary Biosciences,
Cameron Rink, Surgery
Zhong-Lin Lu, Psychology
Jay Zweier, Internal Medicine - Age-related differences in torsional indirect traumatic optic neuropathy
Matthew Reilly, Biomedical Engineering
Colleen Cebulla, Ophthalmology & Visual Science
Mohamed Abdel-Rahman, Ophthalmology & Visual Science
Julie Racine, Ophthalmology (Nationwide Children's Hospital)
Nathan Doble, Optometry
Stacey Choi, Optometry - Cerebrospinal fluid markers of synaptic injury and functional connectivity in Alzheimer's disease
Rawan Tarawneh, Neurology
Douglas Scharre, Neurology
Zhong-Lin Lu, Psychology - Investigating compensatory language processes prompted by rhythm video game therapy in chronic aphasia
Yune Lee, Speech and Hearing Sciences
Stacy Harnish, Speech and Hearing Sciences
Lynne Gauthier, Physical Medicine & Rehabilitation
Roger Crawfis, Computer Science & Engineering - Small molecule activators of glutamate transporter EAAT2 for Alzheimer's disease
Glenn Lin, Neuroscience
John Bruno, Psychology
Min Zhou, Neuroscience - Mechanisms underlying hippocampal cell layer-specific sensitivity to ischemic stroke
Karl Obrietan, Neuroscience
Kari Hoyt, Pharmacology
Pre-projects
- Driving performance after concussion in teens
Ginger Yang, Pediatrics (Nationwide Children's Hospital)
Keith Yeates, Psychology (Nationwide Children's Hospital)
Richard Rodenberg, Pediatrics (Nationwide Children's Hospital)
James McDonald, Pediatrics (Nationwide Children's Hospital)
Thomas Kerwin, Ohio Supercomputer Center
Don Stredney, Ohio Supercomputer Center
Michael Tiso, Sports Medicine
Jennifer Bogner, Physical Medicine & Rehabilitation - The effect of KATP channel manipulation on neuroprotection after stroke
Shahid Nimjee, Neurosurgery
Keli Hu, Pharmacology
Cameron Rink, Surgery
Chanden Sen, Surgery - Neurocognitive versus neuromuscular deficits following mild traumatic brain injury
Asimina Kiourti, Electrical & Computer Engineering
James Onate, Physical Therapy
Stephanie Di Stasi, Sports Medicine
Michael Tiso, Sports Medicine
- Hojjat Adeli, Alexandra Borstad, John Buford
Computer aided prediction of sensory correlates of motor recovery following constraint induced movement therapy in chronic stroke
Civil, Environmental & Geodetic Engineering, Physical Therapy - Daniel Gallego-Perez, L. James Lee, Savita Khanna, Cameron Rink
Pro-angiogenic cell therapies for stroke recovery: Nanoengineering blood vessels through direct reprogramming
Biomedical Engineering, Chemical & Biomolecular Engineering, Surgery - Jonathan Godbout, John Sheridan, Daniel Eiferman
The Elimination of Microglia by a CSF-1R antagonist to prevent or reverse TBI-induced chronic inflammation associated with microglia priming and reactivity
Neuroscience, Dentistry, Surgery - Cameron Rink, Savita Khanna, David McComb
Characterization of collateral remodeling in the stroke-affected brain
Surgery, Materials Science & Engineering - Zachary Weil, Kari Hoyt
Mitochondrial dysfunction mediated by insulin resistance in repeated traumatic brain injury
Neuroscience, Pharmacology
Resource Awards
CBI Resource Awards aim to improve our capabilities for innovative and interdisciplinary research. CBI will fund teams of investigators who seek to acquire shared equipment, personnel, services, or other relevant resources that enhance the research and clinical capabilities of the CBI community.
2023 AWARDS
Acquisition of a Switch-Based Multiport Network Analyzer Solution
Asimina Kiourti, PhD (Electrical & Computer Engineering)
Optogenetic Stimulation and Fiber Photometry
Cole Vonder Haar, PhD (Neuroscience)
CBI Partnership & Engagement Grants (PEGs)
The Chronic Brain Injury Award Program (CBI) supports projects advancing Ohio State's land-grant mission that develop and deepen relationships with community members and organizations. CBI's Partnership & Engagement Grants will support new transdisciplinary research projects involving local, regional, and national community and industry partners.
2023 PEG Award: Harvesting the Social Meaning of Brain Injury
- Maurce Stevens, PhD | Comparative Studies
- Brei Miller, AT, MBA | Ohio Brain Injury Program
2022 PEG Award: Helmets in Girls' Lacrosse: Is There Need for A Change?
- Ginger Yang, PhD | Nationwide Children's Hospital
- Jaclyn Caccese, PhD | Health & Rehab Sciences
- Lissa Fickert & Tyler Brooks | Ohio Health School Athletic Association
Action Potential Grants
CBI Action Potential Grants (APGs) support the development and capture of federally-funded program or center grants that elevate interdisciplinary faculty clusters currently working in basic, clinical, and translational research on chronic brain injury topics. Faculty clusters, or groups of faculty working on interdisciplinary or convergent research within a relevant topic area, can use these awards to develop, coordinate, and submit federal grants. For example, these funds can help teams to form, to discuss and coordinate proposal development, or to acquire resources or services critical to those proposals.
2022 APG Award: Health-enhancing active lifestyle intervention to promote optimal aging, health and function with CBI (HEAL-CBI)
- PI: Catherine Quatman-Yates, PT, DPT, PhD | Physical Therapy
2021 APG Award: Formation of OSU's Transformative, Transdisciplinary Research Program in Brain Trauma from Interpersonal Violence (BT-IPV)
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PI: Julianna Nemeth, PhD | Health Behavior & Health Promotion
SUMMER UNDERGRADUATE RESEARCH FELLOWSHIPS
CBI is proud to award Summer Undergraduate Research Fellowships (SURF Awards) to Ohio State undergraduate students pursuing brain injury research with our faculty affiliates. Each student will spend the summer completing a research project and will present these projects at an upcoming seminar or conference. Fellowships support the student's time, while the mentor provides project funding and training.
OUR RESOURCES
We are excited to offer PREP-Work (Peer Review for Extramural Proposals Workshops), a new resource specifically for CBI Faculty Affiliates to receive feedback on grant proposals currently in development. See our attached guidelines for a full description and deadlines.
Briefly, our team of experienced Ohio State faculty researchers will review up to five proposals per workshop (three workshops per year), and will provide feedback on strengths and weaknesses, opportunities for improvement, and strategic advice. Each participant will receive written comments on their proposal, as well as meet with the reviewers for an informal presentation and discussion. Our goal is to support proposal development and success by maximizing the competitiveness of your grant applications.
The first round of PREP-Work will take place in January 2022, with proposal review requests due December 13, 2021. You can request a review at https://go.osu.edu/cbiprepwork.
If you have any questions, please contact Kedar Hiremath (Hiremath.7@osu.edu).
Zeiss Apotome.2 Microscope
Contact: Elizabeth Kirby, PhD | Psychology | kirby.224@osu.edu
An essential aspect of repairing brain injury is quantifying tissue damage and recovery in experimental paradigms. Microscopy provides a powerful way to visualize the brain in situ using postmortem tissue sections. However, when imaging thick tissue sections, out-of-focus light can make images blurry, obscuring important details in the in-focus plane. Confocal microscopes address the problem of out-of-focus light by using high-precision lasers to create thin optical sections. While confocal technology provides excellent imaging, it is time-consuming, damaging to samples, expensive and high maintenance.
The Zeiss Apotome is a microscope that offers high resolution imaging similar to that of traditional confocal microscopy but in a fraction of the time and with less damage to fluorescent signal. The Apotome uses a traditional fluorescence microscope coupled with a hardware add-on (the apotome) and deconvolution algorithms to create high resolution z-stacks, yielding well-focused images through thick tissue sections. This process yields images 20-50 times faster than traditional confocal technology with only a small loss in resolution.
Olympus FVMPE-RS Multiphoton Laser Scanning Microscope
Contact: Karl Obrietan, PhD | Neuroscience | obrietan.1@osu.edu
The Olympus FVMPE-RS multiphoton imaging system is purpose-built for deep imaging in biological tissue, aimed at revealing both detail and dynamics. Innovative features for efficient delivery and detection of photons in scattering media enable high signal-to-noise ratio acquisition. This translates to bright images with precise details — even from deep within the specimen. High sensitivity is matched with high-speed imaging to capture rapid in vivo responses.
Shimadzu LABNIRS
Contact: Yune Lee, PhD | Speech & Hearing Sciences | lee.7966@osu.edu
Functional near-infrared spectroscopy (fNIRS) is an emerging neuroimaging technology that optically measures brain function similar to fMRI (BOLD signal). Ohio State's LABNIRS device offers a powerful fNIRS system that allows investigators to study brain function during seated and standing tasks, at a patient's bedside, or on a sideline. Investigators can also study people unable to undergo MR imaging due to age, implanted devices, or other restrictions.
Closed Head Impact Modela of Engineered Rotational Acceleration (CHIMERA)
Contact: Olga Kokiko-Cochran, PhD | Neuroscience | olga.kokiko-cochran@osumc.edu
CHIMERA is a translationally relevant platform for human traumatic brain injury (TBI) research. CHIMERA was specifically designed to overcome many of the caveats that limit the translational relevance of most existing TBI models. CHIMERA's innovation lies in its ability to generate, in a biomechanically controlled and reproducible manner, a wide range of TBI severity with completely free head movement.
Neuroscience Core
Contact: Anthony Brown, PhD | Neuroscience | brown.2302@osu.edu
Established in 2004 and funded by a P30 Center Core grant from the National Institutes of Neurological Disorders and Stroke, the Ohio State University Neuroscience Center Core is a vital hub for neuroscience research and collaboration across campus, providing specialized expertise and services that support research into the causes and treatments of neurological disorders
The Center consists of an Administrative Core and four Scientific Cores that are managed by highly trained and experienced staff. These cores serve a broad and collaborative community of more than 40 neuroscientists including approximately 30 PIs on approximately 40 NIH-funded neuroscience projects totaling approximately $12 million in annual NIH funding.
A key feature of these Cores is their flexible service model, which allows them to perform procedures for users or to train users that wish to perform the procedures in the Core facility or in their own laboratories. In this way, the Cores maximize efficiency, offering centralized access to equipment and expertise that would be difficult, costly or impractical to duplicate in individual laboratories, while at the same time providing standardized protocols and ensuring uniform application of best practices so that experiments are performed to the highest standards.
By making these services available to investigators, the Center also encourages the adoption of a broader range of technical approaches by individual investigators, strengthening NINDS-funded research on campus and furthering or expanding the scope of NINDS-funded and other neuroscience projects.
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Administrative Core Provides administrative support and oversight of the scientific cores.
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Injury Core Provides assistance with modeling of brain and spinal cord injury in rodents.
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Behavior Core Provides comprehensive behavioral phenotyping of rodents.
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Imaging Core Provides training and access to confocal microscopes.
Center for Cognitive and Behavioral Brain Imaging
Contact: Ruchika Prakash, PhD | Psychology | prakash.30@osu.edu
The Center for Cognitive and Behavioral Brain Imaging (CCBBI) in the College of Arts and Sciences is a new state-of-the art interdisciplinary research facility dedicated to pursuing structural and functional magnetic resonance imaging (fMRI) studies. It aims to contribute to the development of future brain imaging modalities and to create and disseminate knowledge about brain, mind, and imaging research.
The study of brain functioning and behavior (cognitive neuroscience), is one of the fastest growing fields in psychology and the social and biological sciences more generally. A major contributor to this growth is the development of innovative functional Magnetic Resonance Imaging (fMRI) technology. With a Siemens 3T Prisma system and ancillary equipment to support research spanning the cognitive and behavioral sciences, CCBBI is dedicated to the study of brain mechanisms underlying individuals' cognitive capacity and subjective well-being, as well as dysfunctions of these brain mechanisms in normal aging and mental disorders. CCBBI is open to all scholars exploring the relationship between the human brain and behavior.
CBI awards travel funds for faculty affiliates and their lab members to present chronic brain injury research at national and international conferences. These awards are available to defray attendance costs for in-person and virtual presentations. Each CBI-affiliated lab is eligible for one award per year.
Current Offerings
CBI offers our faculty affiliates professional development opportunities at no charge. Past offerings range from free headshots to multi-session speaker trainings. These opportunities are offered 1-2 times per semester.
Please contact CBI staff if you would like to learn more or if you have an idea for a future offering.